ATF4 and cancer: Besides, drug screening assays have revealed that artesunate might function to treat cancer and research has demonstrated that artesunate could dramatically inhibit the proliferation of invasive tumor in mice model by upregulating the expression levels of DNA damage-inducible transcript 3 (DDIT3) and activating transcription factor 4 (ATF-4) factors which increased the endoplasmic reticulum stress and induced the apoptosis of malignant B cells [32,33].