hs‐CRP ≥ 2.02 mg/L [4.2 (95% CI 1.7‐10); P < .01], IL‐6 ≥ 4.92 pg/mL [7 (95% CI 2.8‐17.7); P < .01], and sCD‐40L ≥ 3.10 ng/mL [5.5 (95% CI 2.2‐13.4); P < .01] were the significant parameters that showed an independent and strong association with atrial fibrillation (Table 2) in comparison to the sinus rhythm in Rh‐MS patients. Here, CD40LG is linked to atrial fibrillation.