According to the research report on the active ingredients of YFSJF, it was indicated that the prevention and treatment of PF mainly involved PI3K/AKT signaling pathway, HIF-1 signaling pathway, TNF signaling pathway, IL-17 signaling pathway, T cell receptor signaling pathway, calcium signaling pathway, and Th17 cell differentiation. Here, TNF is linked to pemphigus foliaceus.