ADGRL3 and pemphigus foliaceus: Studies [21, 22] have shown that quercetin can inhibit AKT/mTOR signaling pathway, reduce inflammatory response and collagen deposition, and alleviate PF by downregulating IL-6, IL-8, TGF-beta, NF-kB, COL-1, COL-3, and VEGF as well as ATG5 and CL3.