Th17 cells can produce a large amount of IL-17, and the most characteristic members of the IL-17 family, IL-17A, and IL-17F, form homodimers or heterodimers to bind the heterodimer IL-17RA and IL-17RC complexes and activate downstream signaling to achieve biological effects such as host defense or the pathogenesis of autoimmune diseases and other inflammatory diseases [32]. The gene discussed is IL17RC; the disease is autoimmune disease.