Our previous studies have demonstrated that RTL aqueous or ethanolic extracts can significantly improve glucose uptake in C2C12 myoblasts, alleviate the tumor necrosis factor (TNF)-α-induced IR in skeletal muscles, and ameliorate hyperglycemia, IR indices, and aorta dysfunction in high-fat-diet-fed streptozotocin-induced T2DM rats [7, 8]. This evidence concerns the gene TNF and Hyperglycemia.