MAPK8 and cancer: Further verification based on GSEA showed that the C2 gene set indicated that the high expression of ITGA5 might be closely related to focal adhesion, ECM receptors, MAPK, JNK, MTOR, WNT, FGF-β, VEGF, and cancer pathways (Figure 10), and the C5 gene set might be mainly involved in extracellular matrix, cell migration, cell secretion, and other biological processes (Figure 11).