As functional consequences of DNA sensing by the cGAS-STING pathway differ according to antigen presenting cells or lymphocytes (4), which had not been the focus of previous articles (1, 2), the present review aims: i) to study arguments for a possible contribution of over-activation of the cGAS-STING pathways to the disturbances of T and B cell responses observed in previous SARS-CoV, and in severe COVID-19 (Table 1); ii) to raise further hypotheses to test in COVID-19 (Table 2). This evidence concerns the gene CGAS and COVID-19.