The striking similarities noticed between SAVI syndromes and signs of severe COVID-19 including pneumonitis (1), inflammatory vasculopathies with acral thrombosis or Kawasaki-like features (2), and the lymphocyte changes described above, are not evidences that the cGAS-STING axis plays a central role in COVID-19 pathogenesis. The gene discussed is STING1; the disease is Venous thrombosis.