STING1 and severe acute respiratory syndrome: Long-term studies on serology kinetics in SARS-CoV and MERS-CoV infections, showed that most IgG were neutralizing but waned over time, and usually in less than 3 years, with longer durations of detectable antibody associated with more severe symptoms (88). Whether gain of function and/or activation of STING in subsets of cTfh cells leading to their premature apoptosis due to hyperresponsiveness to TCR signals, contribute to this rather short duration of antibodies towards SARS-CoV infections has not been addressed so far (Table 2).