This T cell lymphopenia appears to predict morbidity and mortality, even at early stages, while elevated levels of CRP, LDH, D-dimer, as well as decreased blood platelets are only late prognosis factors (20).Therefore, rather than a cytokine storm induced by NF-κB stimulation, a marked and widespread virus-induced lymphopenia may be the real cause of death in many patients (71). The gene discussed is NFKB1; the disease is lymphopenia.