The striking similarities noticed between SAVI syndromes and signs of severe COVID-19 including pneumonitis (1), inflammatory vasculopathies with acral thrombosis or Kawasaki-like features (2), and the lymphocyte changes described above, are not evidences that the cGAS-STING axis plays a central role in COVID-19 pathogenesis. Here, STING1 is linked to deep vein thrombosis.