Taken together, these observations suggest that: (1) IgE-mediated food allergy, like EoE, is associated with epithelial barrier dysfunction of the esophagus; (2) antigen exposure in this context promotes tissue eosinophilia; (3) esophageal eosinophilia during OIT is often asymptomatic; and (4) antigen-driven tissue eosinophilia can resolve or persist resulting in EoE. The gene discussed is IGHE; the disease is Increased total eosinophil count.