• Deceased patients had lower levels of lymphocyte and platelet count. Whereas higher levels of ALT, LDH, creatinine, creatinine kinase, troponin I, Serum ferritin, and D-dimer was observed in deceased patients’ samples• d-DIMER was suggested as a potential marker for COVID-19 severity• Higher IL-6 levels were found in deceased patients. Here, IL6 is linked to COVID-19.