In a study that investigated the association between some clinical parameters and nine single nucleotide polymorphisms (SNPs) involved in nutrition and metabolism in women with and without GDM, the TCF7L2 gene variant rs7903146 showed a strong association with the risk of developing GDM (OR: 2.56; 95% CI: 1.24–5.29). This evidence concerns the gene TCF7L2 and gestational diabetes.