The rs 10830963 was associated cross-sectionally with fasting glucose (p=0.0069), acute insulin response (AIR, p=0.0013), disposition index (p=0.00078), glucose effectiveness (p=0.018), gestational diabetes (OR 1.48; p=0.012), the rate of change of fasting glucose (p=0.043), No association was found with OGTT 30 min and delta insulin (the difference between the 30 min and fasting glucose concentration), 30 min insulin based disposition index and the rate of change in beta cell compensation for insulin resistance. Here, INS is linked to gestational diabetes.