(54) Thr →→→ acetyl-CoA; acetyl-CoA + OAA → citrate, catalyzed by CS; citrate exits the mitochondria through the dicarboxylate carrier; citrate + ATP + CoASH → acetyl-coA + ADP + Pi + OAA by ACLY; OAA → PEP by PCK1; PEP → pyruvate; the terminal reaction is catalyzed by tartrate-resistant acid phosphatases (for considerations related to cancer, see pathway no. 3). Here, PCK1 is linked to cancer.