ME1 and cancer: (16) Glc →→→ PEP; PEP enters the mitochondria through the means outlined in pathway 11; PEP → OAA by PCK2; OAA + Glu →→Kg + Asp by GOT2; Asp exits the mitochondria; Asp + →Kg → Glu + OAA by GOT1; OAA → Mal by MDH1; Mal → pyruvate by ME1 (for considerations related to cancer, see pathway no. 14).