(15) Glc →→→ PEP; PEP enters the mitochondria through the means outlined in pathway 11; PEP → OAA by PCK2; OAA + acetyl-CoA → citrate by CS; citrate exits the mitochondria through the dicarboxylate carrier; citrate + ATP + CoASH → acetyl-coA + ADP + Pi + OAA by ACLY (Chypre et al., 2012); OAA → Mal by MDH1; Mal → pyruvate by ME1 (for considerations related to cancer, see pathway no. 14). Here, ME1 is linked to cancer.