PKM and cancer: Finally, it has been also shown that PKM2 is not even required for the growth of many cancers (Cortes-Cros et al., 2013; Israelsen et al., 2013; Wang et al., 2014; Lunt et al., 2015; Dayton et al., 2016a, 2018; Lau et al., 2017; Tech et al., 2017; Hillis et al., 2018).