This axial activation, combined with the hypothesized role of cathepsin in degrading the MAG (Stebbins et al., 1997), an inner-sheath adhesion molecule important for axon-myelinic stability (Trapp and Quarles, 1982; Pronker et al., 2016), may explain the primary degenerative processes involved in MS-related AMS instability and myelin disintegration. This evidence concerns the gene CTSS and myeloid sarcoma.