NPAS4 and neurodegenerative disease: As a recent achievement in this regard, it was reported that Npas4 controls neuronal homeostasis in epilepsy through the induction of Homer 1a (Shan et al., 2018), and Npas4 also as one of pivotal transcriptional target of Hdac3-mediated repression in neurodegenerative disease (Louis Sam Titus et al., 2019).