EGFR and non-small cell lung carcinoma: To address the mechanism underlying cigarette smoke-triggered EGFR TKI resistance in EGFRWT NSCLC, H292 NSCLC cells, which express EGFRWT and are sensitive to EGFR TKI, were subjected to long-term treatments with CSE or benzo[α]pyrene (B[α]P), a human carcinogen found in tobacco smoke, for at least 3 months to mimic the behavior of chronic smokers with NSCLC [12, 17].