EGFR and neoplasm: Because EGFR TKI inhibited intracellular energy level by ATP depletion by blocking glucose uptake (Fig. 1), we thus examined the activation of AMP-activated protein kinase (AMPK), which is upregulated in response to ATP depletion and subsequently negatively regulates mTOR complex 1 to inhibit protein translation and tumor growth, in the presence of EGFR TKI.