Furthermore, it has been demonstrated that both WT TDP-43, ALS- related TDP-43 and FUS expression perturbs MERCS, which can disturb VAPB–PTPIP51 binding through glycogen synthase kinase 3β (GSK3β) regulation [13, 14], causing impairment of Ca2+ uptake into the mitochondria and ATP production [13, 14]. This evidence concerns the gene RMDN3 and amyotrophic lateral sclerosis.