PGR and ductal breast carcinoma in situ: In univariate analysis, concomitant DCIS in IDC was significantly associated with age (P < 0.001), surgery type (P = 0.008), IDC grade (P < 0.001), molecular subtype (P = 0.001), ER expression (P = 0.034), PR expression (P = 0.019) and 21-gene RS (P = 0.002) (Table 1).