TLR4 and obesity due to melanocortin 4 receptor deficiency: When that AGE production binding to receptors AGEs (RAGE), AGEs trigger generation of reactive oxygen species (ROS) and initiate a downstream pro-inflammatory signaling cascade including activation of RAGE/TLR4 (Toll-like receptors 4)-NF-κB-ROS pathways12 and contribute to both obesity and related inflammatory diseases13.