Also, AGEs storage in adipose tissue by binding to receptors AGEs (RAGE unregulated the production of adipokines, such as adiponectin, leptin, monocyte chemotherapy protein (MCP-1), and plasminogen activator inhibitor type I (PAI-1), which Recent studies have shown that these compound poses a potential risk for cancer and other immune-related diseases through a variety of factors, such as suppressing the immune system and disrupting the regulation of monocytes, basophil, T lymphocytes, and NK cells45,46. This evidence concerns the gene SERPINE1 and cancer.