Top down-regulated mir-375 target genes (\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$${S}_{P}^{\text{mir}|\text{gene}}$$\end{document}SPmir|gene≥ 0.95) included tumor suppressors such as ZFP36L2, CDKN2B, PRKCA, KLF4, and EXT1, suggesting possible protumorigenic activity of circHIPK3 implemented through ceRNA interaction with mir-375. This evidence concerns the gene CDKN2B and neoplasm.