Top mir-10b targets (Pareto score \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$${S}_{P}^{\text{mir}|\text{gene}}$$\end{document}SPmir|gene ≥ 0.95) that were also down-regulated in tumors included HOXD10, KLF4, and PTEN, all of which had well-known tumor-suppressor functions and reduced expression in prostate cancer tissues120–122. The gene discussed is PTEN; the disease is prostate cancer.