ANXA1 and cancer: An endogenous anti-inflammatory mediator with therapeutic potential in cancer is annexin A1 (ANXA1), a 37 kDa glucocorticoid–inducible protein that is involved in several biological processes, promoting apoptosis8, increasing migration and invasion9,10, and reducing11 or promoting10 cell proliferation and survival, a discrepancy that can be dependent on the cell type or differentiation stage12.