When we analyzed the effect of statins and LFA-1 inhibitors on ICAM-mediated adhesion and migration of CLL cells triggered by CXCL12 and CXCL13, key chemokines for CLL cell homing to lymphoid tissues3, all statins and the LFA-1 inhibitors induced a significant reduction on CLL adhesion/invasion induced by CXCL12 and CXCL13. Here, CXCL13 is linked to B-cell chronic lymphocytic leukemia.