Importantly, since LC–MS/MS and IHC methods allowed us to quantitate the pharmacodynamic effect of the type I PRMT inhibitor on hnRNP-A1 in mouse PBMCs and Toledo xenografts, we were able to determine that the dose dependent reduction in ADM-R225-hnRNP-A1 in both blood and tumor tissues is similar in these two compartments following multiple days of dosing (Fig. 8G). Here, HNRNPA1 is linked to neoplasm.