It has a picomolar affinity for Mcl-1 and was demonstrated to disrupt the interaction between Mcl-1 and Bak, inducing apoptosis in AML cell lines (Fig. 2b).99 AMG 176 is an orally administered molecule with superior PK properties, making it an ideal candidate for in vivo studies. This evidence concerns the gene BAK1 and acute myeloid leukemia.