IDH1 and myelodysplastic syndrome: FT-2102 is a potent, orally bioavailable IDH1-mutant inhibitor that has been demonstrated to inhibit 2-HG production in xenograft mouse models and has the potential to penetrate the blood–brain barrier.58 It is currently in phase I clinical trials in combination with ASTX727 (DNA methytransferase inhibitor) (NCT04013880) and in combination with azacitidine or cytarabine in patients with AML or MDS (NCT02719574).