ABT-737 was shown to bind to Bcl-2, Bcl-xL, and Bcl-w with a high affinity (Fig. 2b).80 ABT-737 induces Bak/Bax-dependent apoptosis in AML cells and has activity in vivo.81 Unfortunately, due to a lack of oral bioavailability and water insolubility, ABT-737 lacked clinical potential. This evidence concerns the gene BAK1 and acute myeloid leukemia.