BCL2 and acute myeloid leukemia: Previous studies have demonstrated that both AML cell lines and patient samples have higher mitochondrial mass and low spare reserve capacity that renders them more susceptible to oxidative stressors and more sensitive to respiratory chain inhibitors.186 Lagadinou et al. found that inhibition of Bcl-2 reduced OXPHOS in AML cells and induced cell death in LSCs, demonstrating both the ability to inhibit OXPHOS and target vulnerable subsets of AML cells.17 Below we detail promising OXPHOS inhibitors in AML.