In AML mice xenograft studies, AMG 176 had a dose-dependent reduction in tumor burden when delivered twice weekly.99 Several studies have demonstrated that normal B cells, monocytes, neutrophils, and hematologic progenitor cells depend on Mcl-1, so further studies into the tolerability of AMG 176 included using human Mcl-1 knock-in mouse models to look at the effect of AMG 176 on normal hematopoietic cells. The gene discussed is MCL1; the disease is acute myeloid leukemia.