CDKN1A and neoplasm: When bound to c-Myc, Miz-1 acts to inhibit transcription as it is unable to bind to initiator elements of the tumor-suppressor genes (cdkn2b [p15] or cdkn1a [p21Cip1/Waf1]) and thus supports oncogenic cell cycle progression.250 The DNA methyltransferase DNMT3a is also recruited by c-Myc in this repression process, which methylates CpG islands of this region and further represses the initiation of transcription.250,251