It has a picomolar affinity for Mcl-1 and was demonstrated to disrupt the interaction between Mcl-1 and Bak, inducing apoptosis in AML cell lines (Fig. 2b).99 AMG 176 is an orally administered molecule with superior PK properties, making it an ideal candidate for in vivo studies. The gene discussed is MCL1; the disease is acute myeloid leukemia.