IL3RA and acute lymphoblastic leukemia: IMGN632 (ImmunoGen, Inc.)is an ADC composed of humanized anti-CD123 antibody linked to a cytotoxic compound (DNA mono-alkylating payload of the indolinobenzodiazepine pseudodimer).377 IMGN632 was found to have antileukemic effects without targeting myeloid progenitors and was cytotoxic against PDX models in ALL, which strongly supported its use as a clinical therapy.