PI3K/AKT and mTOR signaling have been extensively linked to supporting AML cell proliferation and survival, but they could also regulate metabolic homeostasis in AML cells and LSCs by several methods.262 Rapidly proliferating bulk AML cells rely on glycolysis for energy production, which is known to be supported through activation of mTORC1 by PI3K/AKT signaling.347 The PI3K/AKT signaling pathway is also one of the several mechanisms that activates c-Myc (in addition to MEK/ERK signaling). Here, MTOR is linked to acute myeloid leukemia.