MYC and acute myeloid leukemia: Development of small molecules that inhibit this dimerization have been challenging, but 10058-F4 was found to inhibit c-Myc through this mechanism and was demonstrated to increase sensitivity of AML cells to cytotoxic drugs, repress colony formation, promote differentiation, and induce apoptosis (Fig. 5a).251,253 Though promising in vitro, in vivo studies with this inhibitor failed due to poor PK and bioavailability.257 Fortunately, it has been a useful research tool for elucidating the vast control of c-Myc on different aspects of cancer, including AML.