CD47 and acute myeloid leukemia: Another immunologic target identified in AML is CD47, which mainly functions as an anti-phagocytic signal that allows expressing cells to evade phagocytosis via macrophages and other phagocytes and has been found to be overexpressed in multiple hematologic malignancies, including AML.379 The expression of CD47 on AML cells promotes immune cell evasion and is related to poor prognosis.