These enzymes include those that support fatty acid synthesis and glutaminolysis, such as fatty acid synthase and the glutamine transporter SLC1A5, as well as nuclear-encoded mitochondrial genes, promoting mitochondrial structure and biogenesis.261,354,355 However, literature that directly links c-Myc and OXPHOS lacks mechanistic studies and this link has yet to be tested in AML. The gene discussed is MYC; the disease is acute myeloid leukemia.