CIN is a feature of the evolution of aggressive colorectal adenocarcinoma right from the outset, being evident in the smallest adenomas, and multiple reports have directly linked oncogenic APC mutations in colorectal cancer with a predisposition to CIN (Dikovskaya et al., 2007; Fodde et al., 2001; Kaplan et al., 2001). The gene discussed is APC; the disease is adenoma.