Conversely, ApcΔSAMP/+ mice, expressing a version of Apc unable to regulate Wnt pathway activity but retaining the microtubule and EB1 binding domains, develop tumours with the same frequency and kinetics as the corresponding Apc1322/+ mice that express Apc lacking these domains (Lewis et al., 2012; Fig. 1C). Here, APC is linked to neoplasm.