The well-established murine model of FAP, ApcMin/+ (multiple intestinal neoplasia; Min), follows a similar pattern of tumour development – despite mono-allelic inactivation of Apc in every cell in the body, tumorigenesis is almost exclusive to the intestinal epithelium (Moser et al., 1990, 1995; Ren et al., 2019; Su et al., 1992). Here, APC is linked to neoplasm.