It is important to highlight that in the present study control but not Rho-EVs demonstrated strong trend towards reduction of Ang-2 secretion levels by both HPMECS and SAECS in the presence of LPS and ARDS plasma, indicating relevance of extracellular vesicle mitochondrial transfer for alleviation of the severity of endothelial injury (figure 7). The gene discussed is ANGPT2; the disease is acute respiratory distress syndrome.