Although this is a statistically significant effect, the animals survive with no apparent problems, in contrast to the lethal increases in mouse skin TEWL induced by inactivation of ichthyosis genes (e.g., with 12R-LOX, eLOX3, SDR9C7 and many others (19, 20, 22, 32, 33, 34)). This evidence concerns the gene LOX and ichthyosis.