APOE and congenital bilateral aplasia of vas deferens from CFTR mutation: We also reanalyzed global RNA-Seq data from three CAVD donor leaflets (25) to specifically determine whether prevalence of apolipoproteins in calcific CAVD tissue could be due to altered levels in local transcription; however, while some apolipoprotein genes tended to increase in the calcific CAVD tissue, only apoE was significantly changed (Fig. 1C).