In SCaBER cells, which shows the basal / squamous signature, expression of EGFR was reversely correlated with MIR31HG. According to another study on lung cancer, by knocking down MIR31HG, reversal of gefitinib resistance was found by regulation of the EGFR/PI3K/AKT signaling pathway [51]. This evidence concerns the gene AKT1 and lung carcinoma.