CRP was higher among the four Kitavans with positive serology for anti-centromere B antibodies, which can be found in a variety of connective tissue diseases (e.g. CREST syndrome [calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, telangiectasia], diffuse systemic sclerosis, primary biliary cirrhosis) but also in patients without apparent connective tissue disease [44]. This evidence concerns the gene CRP and systemic sclerosis.