In contrast, the CRP of the Swedish controls was positively associated with total cholesterol-HDL cholesterol ratio, triglyceride, triglyceride-HDL cholesterol ratio and serum insulin, in line with the putative role of inflammation in dyslipidemia [2, 52, 53] and insulin resistance [54, 55], further suggesting differences between lean traditional populations and populations with a more atherogenic health profile when evaluating CRP associations. This evidence concerns the gene INS and metabolic syndrome.