Aging in WT mice is associated with essential hypertension (Figure 5A and 5C) and a gradual increase in arterial stiffness.49 There is a profound age-related reduction of phospholemman phosphorylation at all phospholemman phosphorylation sites accompanied by increased phospholemman expression in aortic tissue (Figure 5D and 5E). Here, FXYD1 is linked to hypertensive disorder.