Based on the preoperative clinical parameters of the TMA patient cases (Table 1, Table 2) and the D’Amico classification system [17], they represent intermediate (clinical T2b or Gleason n = 7 and PSA >10 and ≤ 20) and high-risk (clinical T2c-3a or Gleason score (GS) = 8 and PSA ≥ 20) PCa. This evidence concerns the gene KLK3 and posterior cortical atrophy.