The Ob-BMST signature of all seven genes (Aspn, Pdgrfb, Postn, Aspn, Sparcl1, Mcam, Fscn1 and Pmepa1), which were upregulated in the bone stroma, as previously identified [5], were indeed expressed in the primary PCa TCGA cohort, as well as in both BM18 and LAPC9 PDXs (Figure S2A). Here, SPARCL1 is linked to posterior cortical atrophy.