In MCF-7 epithelial breast cancer cells, leptin promotes morphological changes to a fibroblast-like appearance along with invadopodia formation and stress fibers, as well as high levels of fibronectin, N-cadherin, vimentin, Snail, Slug, Zeb1, and Twist; Occludin and E-cadherin were also downregulated [77]. The gene discussed is TWIST1; the disease is breast carcinoma.