STAT3 and neoplasm: Various signaling pathways regulate these biological processes during tumor progression, such as the Wnt-β-catenin, Notch-1, ALK5/H2O2, IL-8-JAK2-STAT3, Src-ANXA2-STAT3, and IKKα–Smad signaling pathways [7,9,10,19,20,87].