LEP and breast carcinoma: In breast cancer patients with a high body mass index (BMI) and elevated circulating levels of leptin, the conditioned media from adipose explants showed a high leptin concentration of 57.4 ± 24.1 ng/mL, there was a tissue concentration of 22.18 ± 15.24 ng/mL for overweight patients, and 22.8 ± 10.63 ng/mL for obese patients [156].