In UMUC3 and 647V human urothelial carcinoma cell lines, leptin promotes migration and expression of phospho-NF-κB, NF-κB, Snail, Slug, Y-box-binding protein 1, and COX-2 as well as NF-κB-vimentin-STAT3 signaling (Figure 3G) [196]. This evidence concerns the gene NFKB1 and urothelial carcinoma.