In human cholangiocarcinoma cell lines SK-ChA-1 and TFK-1, leptin stimulates EMT by stimulating cell migration and invasion, decreasing in E-cadherin and β-catenin expression, and increasing vimentin and, N-cadherin expression as well as the proangiogenic capability through the miR-122/PKM2 axis (Figure 3D) [188]. This evidence concerns the gene LEP and cholangiocarcinoma.