Transcriptomic analysis revealed upregulation of genes in the ER stress-unfolded protein response (UPR) axis including stanniocalcin-2 (STC2), a pro-survival component, and fibroblast growth factor 21 (FGF21), a marker of hepatic fat, targets that are increased in NASH patients [36]. Here, FGF21 is linked to metabolic dysfunction-associated steatohepatitis.