The novel DpT class of thiosemicarbazones demonstrate: (1) potent and selective anti-tumor activity; (2) the ability to overcome P-glycoprotein-mediated resistance [11,21]; and (3) can inhibit metastasis via up-regulating NDRG1 [10,17,24,25,27,49,50]. The gene discussed is ABCB1; the disease is neoplasm.