PIP and neoplasm: Furthermore, megabase-long inverted repeats were soon found in tumor cells amplified for various oncogenes (e.g., CCND2, RIN1, MET, PIP, CCND1 or ERBB2 [27,28,29,30,31,32]), while bridge intermediates were reported in tumors amplified for MDM2 or the 11q13 chromosomal region [33,34], and chromatid fusions were observed in tumor cells amplified for MYC [35].