In another animal experiment, it was revealed that administration of grape seed proanthocyanidins to athymic nude mice by oral gavage (5 days per week) markedly inhibited the growth of s.c. A549 and H1299 lung tumor xenografts, which was associated with the induction of apoptotic cell death, increased expression of Bax, reduced expression of anti-apoptotic proteins, and activation of caspase-3 in tumor xenograft cells [23]. The gene discussed is CASP3; the disease is neoplasm.