INS and polycystic ovary syndrome: In the latest randomized, double-blind, controlled study testing the effect of 50 mg/day BCL associated with COC, Moretti et al. [53] have demonstrated the efficacy and tolerability of BCL in the treatment of severe hirsutism in young PCOS patients after 18 months, but without observing any changes in blood pressure, fasting insulin, glucose, waist circumference, and body composition.