These toxins were not found in all EAEC isolated from diarrheal cases, and they were also present in non-diarrheal EAEC isolates, suggesting that potentially other toxins, e.g., SHET1 encoded by set gene, or sepA (secreted autotransporter toxin) found associated with diarrheal disease [19], or the combination of multiple factors/toxins are responsible for diarrhea. The gene discussed is ESPL1; the disease is diarrheal disease.