Liang et al. [73] analyzed the number of CTCs as one of the efficacy parameters for the comparison of three therapy strategies for tumor cryoablation with natural killer (NK) cells therapy (I, cryoablation; II, cryoablation + NK cell therapy; III, NK cell therapy-Herceptin) and Herceptin for patients with HER2-overexpressing recurrent BC. Here, ERBB2 is linked to breast cancer.