In contrast to the pivotal roles play by Lnx1/2 in teleost development, the embryonic functions of LNX1/2 in mammals have remained obscure, since LNX1/2 single- or double-knock-out mice did not show any significant embryonic defects and remained fertile, and only exhibited decreased anxiety-related behavior and marginally lower body weight compared to their wild-type counterparts. Here, LNX1 is linked to Anxiety.