Contrary to expectation, Camps et al. in 2013 [87] showed that LNX2 depletion reduced the levels of both NUMB and NOTCH1 proteins without affecting the levels of NUMB transcripts in SW470 (colorectal cancer cell line) cells, which was counterintuitive, considering that Lnx2 in zebrafish is commonly known to target Numb degradation [21]. This evidence concerns the gene NUMB and colorectal cancer.