PDZRN3 and cervical carcinoma: In contrast, another report showed that the expression level of p53 reduced significantly in HeLa cells, which constitute a cervical carcinoma cell line with multiple copies of integrated high-risk human papillomavirus-18 (HPV-18) DNA [133], when LNX3 was depleted using an siRNA [134]; therefore, the increased cellular levels of LNX3 might induce cell cycle arrest under different cellular contexts.