Recent works from our group have shown that Ang-2 mediated-Tie2 activation induces the production inflammatory mediators by rheumatoid arthritis (RA) and psoriatic arthritis (PsA) macrophages and that Ang-2 neutralization reduces the severity of a mouse model of arthritis [12,14], pointing out the role of Ang-2 in the pathogenesis of these RMDs. This evidence concerns the gene ANGPT2 and Arthritis.