DLG4 and Huntington disease: Major outcomes of the study include (1) reduced latency to escape in the active-avoidance task in SLCP- and SLP-treated mice, (2) increased dendritic arborization and number of dendritic spines on MSNs in HD mice treated with SLCPs or SLPs, (3) reduced PSD95 levels in HD mice treated with SLCPs compared to the HD control mice, and (4) increasing TrkB levels in the SLCP and SLP, along with modest increases in BDNF levels in SLCP-treated HD mice.