These include the phosphatidylinositol-3-kinase (PI3K)/AKT signaling pathway in hepatocellular carcinoma and colon cancer [16,17], Bcl-2 family in lung cancer [18], caspases in breast cancer [19], cyclins in cervical cancer [20], and cytochrome c in osteosarcoma [21]. This evidence concerns the gene AKT1 and breast cancer.