Furthermore, other investigators showed that the sulfated fucoidan (98% purity) obtained from Sargassum fusiforme suppressed cell migration and invasion of hepatocellular cancer cells (HCC SMMC-7721, Huh7, and HCCLM3 cells), and the decreased expression of MMP-2 was speculated to be associated with this outcome [11]. This evidence concerns the gene MMP2 and hepatocellular carcinoma.