Results showed that the amount of CD31 in matrigel and tumor tissues under stimulation by vascular endothelial growth factor (VEGF) was suppressed in a dose-dependent manner by the administration of LMWF (matrigel plug: 0, 25, 50, and 75 μg, T24 tumors: 0, 80, 160, and 300 μg/kg/day). This evidence concerns the gene VEGFA and neoplasm.