Surprisingly, we found that CNV alterations in some olaparib-modulated lncRNAs had a statistically significant correlation with alterations in some key tumor suppressors genes (Figure 5 and Figure S3): samples harboring amplification in FLG-AS1 were frequently mutated in TP53, while there was a negative correlation with mutations in PTEN and IDH1; alterations in SPOP co-occurred with a deep deletion in RGMB-AS1, and alterations in VHL were enriched in samples containing amplification in SNHG4 or in PRR7-AS1. The gene discussed is SPOP; the disease is neoplasm.