Table 1 shows the relationship of CTSB expression and prognostic factors of PTC. Tumor size was larger in High 3 group than low group. Multiplicity was significantly higher in accordance with increasing of expression of CTSB. High expression of CTSB affected LNM and N stage. Immunoblotting of patient samples showed higher CTSB levels in tumor tissue compared to normal tissue (Figure 2A,B), and patients with higher CTSB expression were at increased risk of LNM and advanced N stage (Figure 2C,D). Here, CTSB is linked to neoplasm.