Another flavonoid, astilbin, alleviates disease progression in an SLE-prone mouse model by reducing the production of pro-inflammatory cytokines (IFN-γ, IL-17A, IL-1β, TNF-α, and IL-6) in serum and by decreasing the number of activated T and B cells [27]. The gene discussed is TNF; the disease is systemic lupus erythematosus.