Resveratrol attenuates vascular inflammation by decreasing the expression of Intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion protein 1 (VCAM-1), and monocyte chemoattractant protein 1 (MCP-1) and reduces macrophage infiltration in the aortic tissue of db/db mice a well-established model of obesity and diabetes [67]. This evidence concerns the gene CCL2 and obesity due to melanocortin 4 receptor deficiency.