NOS2 and Parkinson disease: Acacetin has anti-neuroinflammatory effects in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD mouse model by suppressing microglial cells, inhibiting iNOS and COX-2 expression, and reducing dopaminergic cell body loss [103] (Table 3).