Mangiferin attenuates RA severity and reduces IL-1β, TNF-α, IL-6, and receptor activator NF-κB ligand (RANKL) expression in RA-induced mice by suppressing NF-κB and extracellular signal-regulated kinase (ERK)1/2 activation [42]. This evidence concerns the gene NFKB1 and rheumatoid arthritis.