NFKB1 and lung carcinoma: It has been reported that SARS-CoV 3CLpro can cleave cellular V-ATPase G1 in vitro [19], and A549 human lung carcinoma cells overexpressing SARS-CoV 3CLpro showed down-regulated NF-κB production [20], the decreased NF-κB protein level may possibly be a consequence of the proteolytic processing of NF-κB by SARS-CoV 3CLpro.