The transfection of colon cancer cells with anti-c-myc shRNA plasmids not only reduced c-myc expression, but also that of the human telomerase reverse transcriptase gene (hTERT), which is under the transcriptional regulation of c-myc, and also contributes towards carcinogenesis, when abnormally expressed [95]. The gene discussed is MYC; the disease is malignant colon neoplasm.