Deletion of alpha-smooth muscle actin (α-SMA, a marker of myofibroblasts)-positive cells in a pancreatic cancer mouse model (Ptf1-Cre; lox-stop-lox-KrasG12D/+; Tgfbr2lox/lox) leads to invasive, undifferentiated tumors that are more hypoxic and reduces animal survival [13]. This evidence concerns the gene ACTA1 and familial pancreatic carcinoma.