However, conditional deletion of Shh (Shhlox/lox) reduces stromal content, but tumors are more aggressive, undifferentiated, and display increased vascularity in the Pdx1-Cre; lox-stop-lox-KrasG12D; Trp53lox/+ pancreatic cancer mouse model [18]. Here, PDX1 is linked to familial pancreatic carcinoma.