A recent study identified a leucine-rich repeat containing 15 (LRRC15)-positive CAF subpopulation within the PDPN-positive CAF population in pancreatic cancer mouse model (Pdx1-Cre; lox-stop-lox-KrasG12D/+; p16/p19lox/lox) [63]. This evidence concerns the gene PDPN and familial pancreatic carcinoma.