ACTA2 and pancreatic neoplasm: However, the ACTA2 gene (coding α-SMA) expression in patients-derived CAFs and Acta2 gene and α-SMA expression in murine (KPC mice)-derived CAFs or primary PSCs drop when cultured with conditioned media from organoids derived from pancreatic cancer patients or from organoids derived from KPC mice, respectively [36] (see Section 4).