In contrast, mononuclear phagocytes exhibited up‐regulation of chemokines such as CCL4, CCL4L2, and CCL3L3 in the cholangiocarcinoma samples and extracellular remodeling genes such as MMP19, MMP12, and HS3ST2 in the metastatic patients. The gene discussed is HS3ST2; the disease is cholangiocarcinoma.