After weight loss among patients with obesity, circulating levels of these obesity‐related inflammatory mediators such as serum amyloid A (SAA), C‐reactive protein (CRP), pro‐inflammatory cytokines including IL‐6, and chemokines such as CCL2 (CC chemokine ligand 2)/MCP‐1, IL‐8, and CCL5/RANTES (modulation of activation and normal T cell expressed and secreted) decreased.49 This evidence concerns the gene CXCL8 and obesity due to melanocortin 4 receptor deficiency.