It is well known that the obesity is associated with chronic low‐grade inflammation in many tissues including liver, AT, vascular, intestinal, skeletal muscle, kidney, pancreas, and brain tissues,11, 12, 13, 14 which are associated with factors such as monocyte chemotactic protein (MCP‐1), CC chemokine receptor 2 (CCR2), tumor necrosis factor‐α (TNF‐α), toll‐like receptor 4 (TLR4), C‐Jun N‐terminal kinase (JNK), macrophages, and various types of T cells and B cells.15 The gene discussed is CCL2; the disease is obesity due to melanocortin 4 receptor deficiency.