We also found that the clinical signs of experimental colitis were improved, MPO and pro‐inflammatory cytokines (TNF‐α, IL‐6, and IL‐17) were downregulated and anti‐inflammatory cytokine (IL‐10) were upregulated after administration of the miR‐223 agomir, and these changes were reversed after administration of the miR‐223 antagomir. The gene discussed is IL6; the disease is colitis.